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In considering the question of why diseases exist, Dr Moalem proposes that most common diseases came into existence for very good reasons. Diabetes, hemochromatosis, cystic fibrosis and sickle cell anemia may all exist because, at some time in our past, they helped our ancestors survive some grand challenge to human existence. In turn, he also discovers that genetic and cultural differences have led to each race having different and unique ways of reacting to their environment and subsequently how they become susceptible to certain diseases.